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TAP2 a 'transporter associated with antigen processing' (TAP) protein. Member of the ATP binding cassette (ABC) family of transmembrane transporters. Transports peptides across the endoplasmic reticulum membrane for assembly of major histocompatibility complex class I molecules. Two subunits, TAP1 and TAP2, are required for peptide transport. ATP hydrolysis is important for transport activity. Nascent MHC class I molecules associate with TAP via tapasin. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 6p21.32
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; integral to endoplasmic reticulum membrane; integral to membrane; membrane; nuclear speck; phagocytic vesicle membrane; TAP complex
Molecular Function: ATP binding; peptide antigen-transporting ATPase activity; peptide transporter activity; protein binding; TAP1 binding; tapasin binding; transporter activity
Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; cytosol to ER transport; peptide antigen transport
Disease: Bare Lymphocyte Syndrome, Type I
Reference #:  Q03519 (UniProtKB)
Alt. Names/Synonyms: ABC transporter, MHC 2; ABC-transporter; ABC18; ABCB3; antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; ATP-binding cassette, sub-family B (MDR/TAP), member 3; D6S217E; peptide supply factor 2; peptide transporter involved in antigen processing 2; peptide transporter PSF2; peptide transporter TAP2; PSF-2; PSF2; really interesting new gene 11 protein; RING11; TAP2; transporter 2, ABC (ATP binding cassette); transporter 2, ATP-binding cassette, sub-family B; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Gene Symbols: TAP2
Molecular weight: 75,664 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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