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DAPK2 an ubiquitously expressed protein kinase of the DAPK family. Activated by Ca(2+)/calmodulin. Contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain. Overexpression induces apoptosis. Expressed at high levels in heart, lung and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: CAMK group; DAPK family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle
Molecular Function: ATP binding; calmodulin binding; identical protein binding; protein binding; protein serine/threonine kinase activity
Biological Process: anoikis; apoptosis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of autophagy
Reference #:  Q9UIK4 (UniProtKB)
Alt. Names/Synonyms: DAP kinase 2; DAP-kinase-related protein 1; DAPK2; death-associated kinase 2; Death-associated protein kinase 2; DRP-1; DRP1; MGC119312
Gene Symbols: DAPK2
Molecular weight: 42,898 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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