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SLC20A2 Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. Defects in SLC20A2 are the cause of basal ganglia calcification, idiopathic, type 3 (IBGC3). An autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 8p11.21
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: inorganic phosphate transmembrane transporter activity; receptor activity; sodium-dependent phosphate transmembrane transporter activity; sodium:inorganic phosphate symporter activity; sodium:phosphate symporter activity
Biological Process: ion transport; transport
Disease: Basal Ganglia Calcification, Idiopathic, 1
Reference #:  Q08357 (UniProtKB)
Alt. Names/Synonyms: Gibbon ape leukemia virus receptor 2; GLVR-2; GLVR2; hPit2; MLVAR; murine leukemia virus, amphotropic, receptor for; Phosphate transporter 2; PiT-2; PIT2; S20A2; SLC20A2; Sodium-dependent phosphate transporter 2; solute carrier family 20 (phosphate transporter), member 2; Solute carrier family 20 member 2
Gene Symbols: SLC20A2
Molecular weight: 70,392 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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