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K81 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytosol; extracellular space; keratin filament
Molecular Function: protein binding; structural molecule activity
Biological Process: keratinization
Disease: Monilethrix
Reference #:  Q14533 (UniProtKB)
Alt. Names/Synonyms: ghHb1; ghHKb1; Hair keratin K2.9; hard keratin, type II, 1; Hb-1; HB1; hHAKB2-1; K81; keratin 81; Keratin, hair, basic, 1; Keratin, type II cuticular Hb1; Keratin-81; KRT81; KRTHB1; Metastatic lymph node 137 gene protein; MLN 137; MLN137; Type II hair keratin Hb1; Type-II keratin Kb21
Gene Symbols: KRT81
Molecular weight: 54,928 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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