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TUBA1A Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Expressed at a high level in fetal brain. Belongs to the tubulin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component: cytoplasmic microtubule; cytosol; membrane raft; microtubule; microtubule cytoskeleton; myelin sheath; nucleus; recycling endosome
Molecular Function: GTP binding; GTPase activity; protein binding; protein domain specific binding; structural constituent of cytoskeleton; structural molecule activity
Biological Process: cell division; cytoskeleton organization; cytoskeleton-dependent intracellular transport; G2/M transition of mitotic cell cycle; microtubule-based process; regulation of G2/M transition of mitotic cell cycle
Disease: Lissencephaly 3
Reference #:  Q71U36 (UniProtKB)
Alt. Names/Synonyms: Alpha-tubulin 3; B-ALPHA-1; FLJ25113; hum-a-tub1; hum-a-tub2; LIS3; TBA1A; TUBA1A; TUBA3; Tubulin alpha-1A chain; Tubulin alpha-3 chain; Tubulin B-alpha-1; tubulin, alpha 1a; tubulin, alpha 3; tubulin, alpha, brain-specific
Gene Symbols: TUBA1A
Molecular weight: 50,136 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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