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TrkA a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 1q23.1
Cellular Component: early endosome; endosome; integral to plasma membrane; late endosome; plasma membrane; protein complex; receptor complex
Molecular Function: nerve growth factor binding; nerve growth factor receptor activity; neurotrophin binding; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; microtubule-based movement; negative regulation of cell proliferation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; positive regulation of GTPase activity; positive regulation of programmed cell death; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; protein amino acid autophosphorylation; protein amino acid phosphorylation; sympathetic nervous system development
Disease: Insensitivity To Pain, Congenital, With Anhidrosis; Thyroid Carcinoma, Familial Medullary
Reference #:  P04629 (UniProtKB)
Alt. Names/Synonyms: DKFZp781I14186; High affinity nerve growth factor receptor; MTC; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; NTRK1; Oncogene TRK; p140-TrkA; TRK; Trk-A; TRK1; TRK1-transforming tyrosine kinase protein; TRKA; tyrosine kinase receptor A
Gene Symbols: NTRK1
Molecular weight: 87,497 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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