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Syk a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Plays a central role in the B cell receptor (BCR) response. An upstream activator of the PI3K, PLCgamma2, and Rac/cdc42 pathways in the BCR response. Required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis. Expression highest in murine spleen, heart, mammary gland and thymus. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Syk family; TK group
Chromosomal Location of Human Ortholog: 13 A5|13 27.41 cM
Cellular Component: B cell receptor complex; cytoplasm; extrinsic to internal side of plasma membrane; nucleus; protein complex; T cell receptor complex
Molecular Function: ATP binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; phosphatase binding; phosphotyrosine binding; protein binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; SH2 domain binding; ubiquitin protein ligase binding
Biological Process: activation of JNK activity; activation of MAPK activity; adaptive immune response; B cell receptor signaling pathway; beta selection; blood vessel morphogenesis; cell migration; cell surface receptor linked signal transduction; defense response to bacterium; enzyme linked receptor protein signaling pathway; G-protein coupled receptor protein signaling pathway; innate immune response; integrin-mediated signaling pathway; leukocyte activation during immune response; leukocyte adhesion; leukotriene biosynthetic process; lymph vessel development; macrophage activation during immune response; neutrophil activation during immune response; neutrophil chemotaxis; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell differentiation; positive regulation of bone resorption; positive regulation of calcium-mediated signaling; positive regulation of cell adhesion mediated by integrin; positive regulation of cytokine secretion; positive regulation of gamma-delta T cell differentiation; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of interferon type I production; positive regulation of interleukin-3 biosynthetic process; positive regulation of mast cell degranulation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; protein amino acid autophosphorylation; protein amino acid phosphorylation; receptor internalization; regulation of immune response; regulation of neutrophil degranulation; regulation of phagocytosis; regulation of superoxide release; regulation of transcription factor activity; serotonin secretion; serotonin secretion by platelet; transcription factor import into nucleus
Reference #:  P48025 (UniProtKB)
Alt. Names/Synonyms: KSYK; Spleen tyrosine kinase; Syk; Sykb; Tyrosine-protein kinase SYK
Gene Symbols: Syk
Molecular weight: 71,376 Da
Basal Isoelectric point: 7.92  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  PI3K/Akt Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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