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NFI-B Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 4 C3|4 38.4 cM
Cellular Component: fibrillar center; intracellular; nucleus
Molecular Function: DNA binding; DNA binding transcription factor activity; double-stranded DNA binding
Biological Process: anterior commissure morphogenesis; chondrocyte differentiation; DNA replication; forebrain development; glial cell differentiation; hindbrain development; lung development; negative regulation of cell proliferation; negative regulation of DNA binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; principal sensory nucleus of trigeminal nerve development; regulation of transcription, DNA-templated; transcription, DNA-dependent
Reference #:  P97863 (UniProtKB)
Alt. Names/Synonyms: 6720429L07Rik; CCAAT-box-binding transcription factor; CTF; E030026I10Rik; NF-I/B; NF1-B; NFI-B; Nfib; Nuclear factor 1 B-type; Nuclear factor 1/B; Nuclear factor I/B; TGGCA-binding protein
Gene Symbols: Nfib
Molecular weight: 63,507 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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