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Ret a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ret family; TK group
Chromosomal Location of Human Ortholog: 10q11.21
Cellular Component: axon; cell soma; cytosol; dendrite; early endosome; endosome membrane; integral component of plasma membrane; intracellular membrane-bound organelle; membrane raft; plasma membrane; plasma membrane protein complex; receptor complex
Molecular Function: ATP binding; calcium ion binding; protein binding; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: axon guidance; cellular response to retinoic acid; embryonic epithelial tube formation; enteric nervous system development; homophilic cell adhesion; MAPK cascade; membrane protein proteolysis; neural crest cell migration; neuron adhesion; neuron maturation; peptidyl-tyrosine phosphorylation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of cell size; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of metanephric glomerulus development; positive regulation of neuron maturation; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of transcription, DNA-templated; posterior midgut development; protein amino acid phosphorylation; regulation of axonogenesis; regulation of cell adhesion; regulation of molecular function; response to drug; response to pain; retina development in camera-type eye; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; ureteric bud development
Disease: Hirschsprung Disease, Susceptibility To, 1; Multiple Endocrine Neoplasia, Type Iia; Multiple Endocrine Neoplasia, Type Iib; Thyroid Carcinoma, Familial Medullary; Thyroid Carcinoma, Papillary
Reference #:  P07949 (UniProtKB)
Alt. Names/Synonyms: Cadherin family member 12; cadherin-related family member 16; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; PTC; RET; ret proto-oncogene; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); RET transforming sequence; RET-ELE1; RET51
Gene Symbols: RET
Molecular weight: 124,319 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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