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NFE2L1 Activates erythroid-specific, globin gene expression. Interacts with KEAP1. Belongs to the bZIP family. CNC subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; integral component of membrane; nucleus; protein complex
Molecular Function: DNA binding transcription factor activity; protein binding; protein complex binding; protein domain specific binding; transcription cofactor activity
Biological Process: anatomical structure morphogenesis; erythrocyte differentiation; heme biosynthetic process; inflammatory response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Reference #:  Q14494 (UniProtKB)
Alt. Names/Synonyms: FLJ00380; HBZ17; LCR-F1; Locus control region-factor 1; NF-E2-related factor 1; NF2L1; NFE2-related factor 1; NFE2L1; NRF1; nuclear factor (erythroid-derived 2)-like 1; Nuclear factor erythroid 2-related factor 1; Nuclear factor, erythroid derived 2, like 1; TCF-11; TCF11; Transcription factor 11; transcription factor 11 (basic leucine zipper type); Transcription factor HBZ17; Transcription factor LCR-F1
Gene Symbols: NFE2L1
Molecular weight: 84,704 Da
Basal Isoelectric point: 4.52  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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