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Protein Page:
Kaiso

Overview
Kaiso Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; plasma membrane
Molecular Function: metal ion binding; methyl-CpG binding; protein binding; sequence-specific DNA binding
Biological Process: negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; Wnt signaling pathway
Reference #:  Q86T24 (UniProtKB)
Alt. Names/Synonyms: KAISO; kaiso transcription factor; Transcriptional regulator Kaiso; WUGSC:H_DJ525N14.1; ZBTB33; zinc finger and BTB domain containing 33; Zinc finger and BTB domain-containing protein 33; ZNF-kaiso; ZNF348
Gene Symbols: ZBTB33
Molecular weight: 74,484 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
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Kaiso

Protein Structure Not Found.
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