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MAPKAPK5 a member of the MAPKAPK family of protein kinases. Activated through phosphorylation by MAP kinases including ERK, p38-alpha, and MAPp38-beta In response to cellular stress and proinflammatory cytokines. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC; Kinase, protein; MAPKAPK family; MAPKAPK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 12q24.12-q24.13
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase binding; p53 binding; protein binding; protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; cell surface receptor signaling pathway; MAPK cascade; negative regulation of TOR signaling; peptidyl-serine phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein autophosphorylation; Ras protein signal transduction; regulation of translation; signal transduction; stress-induced premature senescence
Reference #:  Q8IW41 (UniProtKB)
Alt. Names/Synonyms: MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPK5; MAPKAP kinase 5; MAPKAPK-5; MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; p38-regulated/activated protein kinase; PRAK
Gene Symbols: MAPKAPK5
Molecular weight: 54,220 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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