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Protein Page:
PHF10

Overview
PHF10 Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Belongs to the SAYP family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: nucleus
Reference #:  Q8WUB8 (UniProtKB)
Alt. Names/Synonyms: BAF45A; BRG1-associated factor 45a; BRG1-associated factor, 45-KD, A; FLJ10975; MGC111009; PHD finger protein 10; PHD finger protein 10, isoform a; PHD zinc finger protein XAP135; PHF10; XAP135
Gene Symbols: PHF10
Molecular weight: 56,051 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
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PHF10

Protein Structure Not Found.

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