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ZFP91 Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component: nucleolus; nucleus
Molecular Function: ubiquitin-protein ligase activity
Biological Process: activation of NF-kappaB-inducing kinase
Reference #:  Q96JP5 (UniProtKB)
Alt. Names/Synonyms: FKSG11; PZF; Zfp-91; ZFP91; Zinc finger protein 91 homolog; zinc finger protein 91 homolog (mouse); zinc finger protein homologous to Zfp91 in mouse; ZNF757
Gene Symbols: ZFP91
Molecular weight: 63,445 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
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