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SLC22A4 Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). Genetic variations in SLC22A4 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: apical plasma membrane; integral component of plasma membrane; mitochondrion; plasma membrane
Molecular Function: ATP binding; carnitine transmembrane transporter activity; cation:cation antiporter activity; nucleotide binding; organic anion transmembrane transporter activity; PDZ domain binding; protein binding; quaternary ammonium group transmembrane transporter activity; secondary active organic cation transmembrane transporter activity; symporter activity
Biological Process: body fluid secretion; carnitine metabolic process; carnitine transport; organic anion transport; organic cation transport; quaternary ammonium group transport; sodium ion transport; triacylglycerol metabolic process
Disease: Rheumatoid Arthritis
Reference #:  Q9H015 (UniProtKB)
Alt. Names/Synonyms: Ergothioneine transporter; ET transporter; ETT; integral membrane transport protein; MGC34546; MGC40524; OCTN1; Organic cation/carnitine transporter 1; S22A4; SLC22A4; solute carrier family 22 (organic cation/ergothioneine transporter), member 4; Solute carrier family 22 member 4; UT2H
Gene Symbols: SLC22A4
Molecular weight: 62,155 Da
Basal Isoelectric point: 6.85  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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