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MLK3 a TKL kinase of the MLK family. Has an amino-terminal SH3 domain followed by the kinase domain, two leucine zipper domains, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. Phosphorylates IkappaB and activates SEK1 and MKK7. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; MLK family; MLK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: centrosome; cytoplasm; membrane; microtubule
Molecular Function: ATP binding; identical protein binding; JUN kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process: activation of JNK activity; activation of JNKK activity; activation of MAPK activity; cell death; cell proliferation; JNK cascade; microtubule-based process; positive regulation of apoptosis; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of neuron apoptotic process; protein amino acid phosphorylation; protein autophosphorylation
Reference #:  Q16584 (UniProtKB)
Alt. Names/Synonyms: M3K11; MAP3K11; MEKK11; MGC17114; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; MLK-3; MLK3; protein-tyrosine kinase PTK1; PTK1; SH3 domain-containing proline-rich kinase; SPRK; Src-homology 3 domain-containing proline-rich kinase
Gene Symbols: MAP3K11
Molecular weight: 92,688 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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