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SLCO1B1 Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. Defects in SLCO1B1 are a cause of hyperbilirubinemia, Rotor type (HBLRR). An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Belongs to the organo anion transporter (TC 2.A.60) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 12p12.1
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: bile acid transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; thyroid hormone transmembrane transporter activity
Biological Process: bile acid and bile salt transport; organic anion transport; sodium-independent organic anion transport
Disease: Hyperbilirubinemia, Rotor Type
Reference #:  Q9Y6L6 (UniProtKB)
Alt. Names/Synonyms: Liver-specific organic anion transporter 1; LST-1; LST1; MGC133282; OATP-2; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6; SLCO1B1; SO1B1; Sodium-independent organic anion-transporting polypeptide 2; solute carrier family 21 (organic anion transporter), member 6; Solute carrier family 21 member 6; Solute carrier organic anion transporter family member 1B1; solute carrier organic anion transporter family, member 1B1
Gene Symbols: SLCO1B1
Molecular weight: 76,449 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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