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Protein Page:

Cbl-c Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: lipid raft; plasma membrane
Molecular Function: epidermal growth factor receptor binding; phosphotyrosine binding; receptor tyrosine kinase binding; SH3 domain binding; zinc ion binding
Biological Process: negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
Reference #:  Q9ULV8 (UniProtKB)
Alt. Names/Synonyms: Cas-Br-M (murine) ecotropic retroviral transforming sequence c; Cas-Br-M (murine) ectropic retroviral transforming sequence c; CBL-3; CBL-SL; CBL3; CBLC; RING finger protein 57; RNF57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C
Gene Symbols: CBLC
Molecular weight: 52,456 Da
Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
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