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CDC23 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC8/CDC23 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: anaphase-promoting complex; cytosol; intracellular; nucleoplasm
Molecular Function: protein binding; ubiquitin-protein transferase activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; metaphase/anaphase transition of mitotic cell cycle; mitotic cell cycle; mitotic metaphase plate congression; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of exit from mitosis; regulation of mitotic metaphase/anaphase transition; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; ubiquitin-dependent protein catabolic process
Reference #:  Q9UJX2 (UniProtKB)
Alt. Names/Synonyms: ANAPC8; anaphase promoting complex subunit 8; Anaphase-promoting complex subunit 8; APC8; CDC23; cell division cycle 23 homolog (S. cerevisiae); Cell division cycle protein 23 homolog; Cyclosome subunit 8
Gene Symbols: CDC23
Molecular weight: 68,834 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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