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ZNF198 a probable transcriptional regulator of the krueppel C2H2-type zinc-finger protein family. The translocation between FGFR and ZNF198 (8;13)(p11;q12) is oncogenic, causing stem cell leukemia lymphoma syndrome (SCLL), a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The transforming activity of ZNF198-FGFR1 requires the proline-rich domains, but not the ZNF domains, of ZNF198. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 13q12.11
Cellular Component: cytoplasm; cytosol; PML body
Molecular Function: DNA binding; protein binding; protein-tyrosine kinase activity; ubiquitin conjugating enzyme binding
Biological Process: cytoskeleton organization and biogenesis; multicellular organismal development; regulation of cell morphogenesis
Reference #:  Q9UBW7 (UniProtKB)
Alt. Names/Synonyms: FIM; fused in myeloproliferative disorder; Fused in myeloproliferative disorders protein; MYM; RAMP; rearranged in an atypical myeloproliferative disorder; Rearranged in atypical myeloproliferative disorder protein; SCLL; Zinc finger MYM-type protein 2; Zinc finger protein 198; zinc finger, MYM-type 2; ZMYM2; ZNF198
Gene Symbols: ZMYM2
Molecular weight: 154,911 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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