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DLAT the E2 component of the pyruvate dehydrogenase complex (PDHC) that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. Contains two lipoyl-binding domains. The PDHC plays a major role in controlling the balance between lipid and glucose oxidation depending on substrate availability. The activity of the PDHC is tightly regulated by phosphorylation of the E1 components by the PDHKs. The pyruvate dehydrogenase (PDH) holoenzyme is a multi-enzyme complex (PDHC) that contains 20-30 copies of pyruvate decarboxylase tetramers (2 alpha:2 beta)(E1), 60 copies of dihydrolipoamide acetyltransferase (E2), six homo-dimers of dihydrolipoamide dehydrogenase (E3), plus E3 binding proteins. PDHKs are recruited to the PDHC by binding to a lipoyl group covalently attached to K174 of the inner lipoyl domain of the E2 component. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC; Mitochondrial; Transferase
Chromosomal Location of Human Ortholog: 11q23.1
Cellular Component: mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion; myelin sheath; pyruvate dehydrogenase complex
Molecular Function: dihydrolipoyllysine-residue acetyltransferase activity; protein binding
Biological Process: acetyl-CoA biosynthetic process from pyruvate; glucose metabolic process; pyruvate metabolic process; regulation of acetyl-CoA biosynthetic process from pyruvate; sleep; tricarboxylic acid cycle
Disease: Pyruvate Dehydrogenase E2 Deficiency
Reference #:  P10515 (UniProtKB)
Alt. Names/Synonyms: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoamide S-acetyltransferase; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; DLAT; DLTA; E2 component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; ODP2; PBC; PDC-E2; PDCE2; Pyruvate dehydrogenase complex component E2
Gene Symbols: DLAT
Molecular weight: 68,997 Da
Basal Isoelectric point: 7.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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