Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:
ERK1

Overview
ERK1 a serine/threonine kinase of the GMGC group that plays a critical role in the regulation of cell growth and differentiation. ERK1 (MAPK3) and ERK2 (MAPK1) play central roles in MAPK cascades and are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Depending on the cellular context, MAPK cascades mediate diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. MAPK cascades also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by upstream MAP kinase kinases, MEK1 and -2. Phosphorylation of both the threonine and tyrosine are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC 2.7.11.24; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: caveola; cytoplasm; cytoskeleton; cytosol; early endosome; extracellular exosome; focal adhesion; Golgi apparatus; late endosome; mitochondrion; nuclear envelope; nucleoplasm; nucleus; plasma membrane; protein complex; pseudopodium
Molecular Function: ATP binding; identical protein binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; phosphatase binding; phosphotyrosine binding; protein binding; protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; apoptosis; arachidonic acid metabolic process; axon guidance; Bergmann glial cell differentiation; BMP signaling pathway; cartilage development; caveolin-mediated endocytosis; cell cycle; cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to reactive oxygen species; DNA damage induced protein phosphorylation; ERK1 and ERK2 cascade; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; fibroblast growth factor receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; MAPK cascade; negative regulation of apolipoprotein binding; outer ear morphogenesis; peptidyl-serine phosphorylation; peptidyl-tyrosine autophosphorylation; phosphorylation; platelet activation; positive regulation of cyclase activity; positive regulation of cytokine secretion involved in immune response; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of histone acetylation; positive regulation of histone phosphorylation; positive regulation of macrophage chemotaxis; positive regulation of metallopeptidase activity; positive regulation of protein phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of transcription from RNA polymerase II promoter; positive regulation of translation; positive regulation of xenophagy; protein amino acid phosphorylation; protein complex assembly; regulation of cellular pH; regulation of cellular response to heat; regulation of cytoskeleton organization; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of ossification; regulation of phosphatidylinositol 3-kinase signaling; regulation of stress-activated MAPK cascade; regulation of transcription factor activity; response to exogenous dsRNA; response to toxin; sensory perception of pain; stress-activated MAPK cascade; thymus development; thyroid gland development; transcription initiation from RNA polymerase I promoter; viral process
Reference #:  P27361 (UniProtKB)
Alt. Names/Synonyms: ERK; ERK-1; ERK1; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; HS44KDAP; HUMKER1A; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; MAPK3; MGC20180; Microtubule-associated protein 2 kinase; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; MK03; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3
Gene Symbols: MAPK3
Molecular weight: 43,136 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ERK1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

Substrate Sequence Logo
Sequence Logo

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein