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SIPA1 GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: cytosol; membrane; nucleus; perinuclear region of cytoplasm; protein complex; transport vesicle
Molecular Function: GTPase activator activity; protein binding; protein C-terminus binding
Biological Process: cell proliferation; cellular response to water deprivation; cytoskeleton organization; negative regulation of cell adhesion; negative regulation of cell cycle; negative regulation of cell growth; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Reference #:  Q96FS4 (UniProtKB)
Alt. Names/Synonyms: GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; signal-induced proliferation-associated 1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; Sipa-1; SIPA1; SPA1
Gene Symbols: SIPA1
Molecular weight: 112,149 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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