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SLCO4A1 Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate. Belongs to the organo anion transporter (TC 2.A.60) family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: integral component of plasma membrane; plasma membrane
Molecular Function: sodium-independent organic anion transmembrane transporter activity; thyroid hormone transmembrane transporter activity
Biological Process: sodium-independent organic anion transport; thyroid hormone transport; transmembrane transport
Reference #:  Q96BD0 (UniProtKB)
Alt. Names/Synonyms: Colon organic anion transporter; OATP-E; OATP-RP1; OATP1; OATP4A1; OATPE; OATPRP1; Organic anion transporter polypeptide-related protein 1; organic anion transporting polypeptide E; Organic anion-transporting polypeptide E; POAT; SLC21A12; SLCO4A1; SO4A1; Sodium-independent organic anion transporter E; solute carrier family 21 (organic anion transporter), member 12; Solute carrier family 21 member 12; Solute carrier organic anion transporter family member 4A1; solute carrier organic anion transporter family, member 4A1
Gene Symbols: SLCO4A1
Molecular weight: 77,193 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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