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HER4 a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EGFR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 2q34
Cellular Component: basolateral plasma membrane; cytosol; extracellular region; integral component of membrane; mitochondrial matrix; mitochondrion; nucleoplasm; nucleus; plasma membrane; receptor complex
Molecular Function: ATP binding; epidermal growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein homodimerization activity; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; signal transducer, downstream of receptor, with protein tyrosine kinase activity; transcription regulatory region DNA binding; transmembrane receptor protein tyrosine kinase activity
Biological Process: cell fate commitment; cell migration; cell proliferation; cellular response to epidermal growth factor stimulus; central nervous system morphogenesis; embryonic pattern specification; ERBB2 signaling pathway; heart development; lactation; MAPK cascade; mitochondrial fragmentation involved in apoptotic process; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of ERBB signaling pathway; negative regulation of neuron migration; nervous system development; neural crest cell migration; olfactory bulb interneuron differentiation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphatidylinositol phosphorylation; positive regulation of apoptosis; positive regulation of cardiac muscle cell proliferation; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling; positive regulation of protein localization to cell surface; positive regulation of protein phosphorylation; positive regulation of STAT protein import into nucleus; positive regulation of transcription, DNA-templated; positive regulation of tyrosine phosphorylation of STAT protein; protein autophosphorylation; regulation of cell migration; regulation of cell motility; regulation of molecular function; signal transduction; transcription, DNA-dependent; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Amyotrophic Lateral Sclerosis 19
Reference #:  Q15303 (UniProtKB)
Alt. Names/Synonyms: avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; ERBB4; HER4; MGC138404; p180erbB4; Proto-oncogene-like protein c-ErbB-4; Receptor tyrosine-protein kinase erbB-4; Tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Gene Symbols: ERBB4
Molecular weight: 146,808 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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