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EEF2K an atypical protein kinase of the Alpha family. Dependent on Ca2 ions and calmodulin. May play a key role linking cellular energy status and the inhibition of protein synthesis, a major consumer of metabolic energy. Phosphorylates and inactivates eEF2, resulting in the inhibition of peptide-chain elongation eEF2K is phosphorylated and activated by AMPK in response to elevated AMP levels, which increase during cellular stress and starvation. Regulated in response to a range of stimuli including TNF-alpha. Overexpressed in breast cancer cell lines and tumors. Activated in rat glioblastoma, and growth was inhibited by the drug Rottlerin. Activity induced in ischemic heart muscle Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; Alpha family; EC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation; eEF2K subfamily
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component: cytoplasm; cytosol
Molecular Function: calmodulin binding; elongation factor-2 kinase activity; protein kinase activity; translation factor activity, nucleic acid binding
Biological Process: protein amino acid autophosphorylation; translational elongation
Reference #:  O00418 (UniProtKB)
Alt. Names/Synonyms: Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase; calmodulin-dependent protein kinase III; eEF-2 kinase; eEF-2K; EEF2K; EF2K; elongation factor 2 kinase; elongation factor-2 kinase; Eukaryotic elongation factor 2 kinase; eukaryotic elongation factor-2 kinase; HSU93850; MGC45041
Gene Symbols: EEF2K
Molecular weight: 82,144 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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