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MPG Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. Belongs to the DNA glycosylase MPG family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: nucleoplasm
Molecular Function: alkylbase DNA N-glycosylase activity; damaged DNA binding; DNA N-glycosylase activity; DNA-3-methyladenine glycosylase activity; protein binding
Biological Process: base-excision repair; depurination; DNA dealkylation involved in DNA repair
Reference #:  P29372 (UniProtKB)
Alt. Names/Synonyms: 3' end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p; 3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; 3MG; AAG; ADPG; alkyladenine DNA glycosylase; ANPG; APNG; CRA36.1; CRA36.1 (3-methyl-adenine DNA glycosylase); DNA-3-methyladenine glycosylase; MDG; MID1; MPG; N-methylpurine-DNA glycosylase; N-methylpurine-DNA glycosylase, MPG; PIG11; PIG16; proliferation-inducing protein 11; proliferation-inducing protein 16
Gene Symbols: MPG
Molecular weight: 32,869 Da
Basal Isoelectric point: 9.65  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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