Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

CDK1 a protein kinase of the CDK family. Catalytic subunit of the conserved protein complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions. Mitotic cyclins stably associate with this protein and function as regulatory subunits. Its activity is controlled by cyclin availability and phosphorylation through the cell cycle. Activated in many cancers including colon, liver and breast. The T isoform, which lacks a regulatory region, is expressed in breast cancer. Inhibition in cancer cells may drive cells into apoptosis. May also drive cell migration. Inhibitors: BMS-265246, BMS-265246-01. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK1 subfamily; CDK1 subfamily; CMGC group; Cell cycle regulation; EC; EC; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 10q21.2
Cellular Component: centrosome; cyclin-dependent protein kinase holoenzyme complex; cytosol; endoplasmic reticulum membrane; extracellular exosome; membrane; midbody; mitochondrial matrix; mitochondrion; nuclear chromosome, telomeric region; nucleoplasm; nucleus; spindle microtubule
Molecular Function: ATP binding; chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; histone kinase activity; Hsp70 protein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; viral receptor activity
Biological Process: activation of MAPK activity; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; apoptosis; cell aging; cell division; cell migration; cell proliferation; cellular response to hydrogen peroxide; centrosome cycle; chromosome condensation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; DNA replication; entry of virus into host cell; epithelial cell differentiation; G2/M transition of mitotic cell cycle; Golgi disassembly; histone phosphorylation; microtubule cytoskeleton organization; mitotic cell cycle G2/M transition DNA damage checkpoint; mitotic nuclear envelope disassembly; negative regulation of apoptosis; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; organ regeneration; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of DNA replication; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of protein import into nucleus, translocation; positive regulation of protein localization to nucleus; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; pronuclear fusion; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; protein complex assembly; protein deubiquitination; protein localization to kinetochore; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of embryonic development; regulation of G2/M transition of mitotic cell cycle; regulation of gene expression; regulation of meiotic cell cycle; regulation of Schwann cell differentiation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; response to activity; response to amine; response to axon injury; response to cadmium ion; response to copper ion; response to drug; response to ethanol; response to organic cyclic compound; response to toxin; transcription initiation from RNA polymerase II promoter; ventricular cardiac muscle cell development
Reference #:  P06493 (UniProtKB)
Alt. Names/Synonyms: CDC2; CDC28A; CDK1; cell cycle controller CDC2; Cell division control protein 2 homolog; cell division cycle 2; cell division cycle 2, G1 to S and G2 to M; Cyclin-dependent kinase 1; DKFZp686L20222; MGC111195; p34 protein kinase; P34CDC2
Gene Symbols: CDK1
Molecular weight: 34,095 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  ErbB/HER Signaling  |  G2/M DNA Damage Checkpoint  |  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

Substrate Sequence Logo
Sequence Logo

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein