a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK2 family; EC 184.108.40.206; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Molecular Function: ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; glutamate receptor binding; identical protein binding; kinase activity; metal ion binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: angiotensin-activated signaling pathway; calcium ion transport; cell differentiation; dendrite morphogenesis; G1/S transition of mitotic cell cycle; MAPK cascade; nervous system development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of calcium ion transport; positive regulation of cardiac muscle cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; protein amino acid phosphorylation; protein autophosphorylation; regulation of cellular response to heat; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of neuronal synaptic plasticity; regulation of neurotransmitter secretion; Wnt receptor signaling pathway, calcium modulating pathway
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; calmodulin-dependent kinase II; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaM-kinase II alpha chain; CaMK-II alpha subunit; CaMK-II subunit alpha; CAMK2A; CAMKA; CaMKII; CaMKIINalpha; KCC2A; KIAA0968