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ERG Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. Defects in ERG are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving ERG is found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1. Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4. Belongs to the ETS family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 21q22.2
Cellular Component: nucleus; ribonucleoprotein complex
Molecular Function: DNA binding; protein binding; signal transducer activity
Biological Process: cell differentiation; cell proliferation; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; signal transduction
Reference #:  P11308 (UniProtKB)
Alt. Names/Synonyms: ERG; erg-3; ets-related; p55; TMPRSS2-ERG prostate cancer specific; Transcriptional regulator ERG; transcriptional regulator ERG (transforming protein ERG); Transforming protein ERG; v-ets avian erythroblastosis virus E26 oncogene related; v-ets erythroblastosis virus E26 oncogene homolog (avian); v-ets erythroblastosis virus E26 oncogene like
Gene Symbols: ERG
Molecular weight: 54,608 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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