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KCNN4 Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 19q13.31
Cellular Component: cell soma; plasma membrane; vesicle; voltage-gated potassium channel complex
Molecular Function: calcium-activated potassium channel activity; calmodulin binding; potassium channel activity; protein binding; protein phosphatase binding; small conductance calcium-activated potassium channel activity
Biological Process: calcium ion transport; defense response; positive regulation of T cell receptor signaling pathway; potassium ion transport; stabilization of membrane potential
Disease: Dehydrated Hereditary Stomatocytosis 2
Reference #:  O15554 (UniProtKB)
Alt. Names/Synonyms: hIKCa1; hKCa4; hSK4; IK1; IKCA1; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCA4; KCNN4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; Putative Gardos channel; SK4; SKCa 4; SKCa4
Gene Symbols: KCNN4
Molecular weight: 47,696 Da
Basal Isoelectric point: 9.87  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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