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Protein Page:
mTOR

Overview
mTOR an atypical kinase belonging to the PIKK family of kinases. Is the catalytic subunit of two protein complexes, mTORC1 and mTORC2. mTORC1 activates S6K and inactivates 4E-BP1, up-regulating protein synthesis. mTORC1 contains Raptor, a positive regulatory subunit and scaffold for recruiting substrates, two negative regulators, PRAS40 and DEPTOR, and mLST8; it is a target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. mTORC2, a downstream effector of PI3K, is insensitive to rapamycin and activates Akt by phosphorylating a key activation site. mTORC2 contains regulatory subunits Rictor and mSIN1, PROTOR, mLST8, and the negative regulator DEPTOR. mTORC1 suppresses PI3K activity via a strong negative feedback loop that involves S6K1. Inhibiting mTORC1 ablates this negative feedback loop and potentiates PI3K signaling. Known inhibitors of mTOR include rapamycin, temsirolimus (CCI-779). Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; Autophagy; EC 2.7.11.1; FRAP subfamily; Kinase, protein; Motility/polarity/chemotaxis; PIKK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: cell soma; cytoplasm; cytosol; dendrite; endomembrane system; endoplasmic reticulum membrane; Golgi membrane; lysosomal membrane; lysosome; membrane; mitochondrial outer membrane; nucleoplasm; nucleus; phosphoinositide 3-kinase complex; PML body; TORC2 complex
Molecular Function: ATP binding; identical protein binding; kinase activity; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; ribosome binding
Biological Process: activation of protein kinase B activity; anoikis; brain development; cardiac muscle cell development; cardiac muscle contraction; cell aging; cell cycle arrest; cellular response to amino acid starvation; cellular response to hypoxia; cellular response to leucine starvation; cellular response to nutrient levels; cellular response to starvation; de novo'pyrimidine base biosynthetic process; DNA repair; energy reserve metabolic process; germ cell development; growth; heart morphogenesis; heart valve morphogenesis; long-term memory; maternal process involved in female pregnancy; mRNA stabilization; multicellular organism growth; negative regulation of autophagy; negative regulation of cell size; negative regulation of cholangiocyte apoptotic process; negative regulation of iodide transmembrane transport; negative regulation of macroautophagy; negative regulation of muscle atrophy; negative regulation of NFAT protein import into nucleus; negative regulation of protein phosphorylation; negative regulation of protein ubiquitination; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of cholangiocyte proliferation; positive regulation of eating behavior; positive regulation of endothelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of granulosa cell proliferation; positive regulation of keratinocyte migration; positive regulation of lamellipodium assembly; positive regulation of lipid biosynthetic process; positive regulation of myotube differentiation; positive regulation of neuron death; positive regulation of neuron maturation; positive regulation of nitric oxide biosynthetic process; positive regulation of oligodendrocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of sensory perception of pain; positive regulation of skeletal muscle hypertrophy; positive regulation of smooth muscle cell proliferation; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; post-embryonic development; protein amino acid phosphorylation; protein autophosphorylation; protein catabolic process; regulation of actin cytoskeleton organization; regulation of brown fat cell differentiation; regulation of carbohydrate utilization; regulation of cell growth; regulation of cell size; regulation of cellular response to heat; regulation of fatty acid beta-oxidation; regulation of glycogen biosynthetic process; regulation of GTPase activity; regulation of macroautophagy; regulation of membrane permeability; regulation of myelination; regulation of osteoclast differentiation; regulation of response to food; response to amino acid; response to cocaine; response to insulin stimulus; response to morphine; response to nutrient; ruffle organization; signal transduction; social behavior; spinal cord development; TOR signaling; TORC1 signaling; visual learning; voluntary musculoskeletal movement; wound healing
Disease: Focal Cortical Dysplasia Of Taylor; Smith-kingsmore Syndrome
Reference #:  P42345 (UniProtKB)
Alt. Names/Synonyms: FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FKBP12-rapamycin complex-associated protein 1; FLJ44809; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); mTOR; RAFT1; rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; Rapamycin target protein 1; RAPT1; Serine/threonine-protein kinase mTOR
Gene Symbols: MTOR
Molecular weight: 288,892 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Angiogenesis  |  Autophagy Signaling  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  IL6 Signaling  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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mTOR

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