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NOLC1 Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: Cajal body; cytoplasm; nucleolus
Molecular Function: ATP binding; GTP binding; protein binding; protein heterodimerization activity; RNA binding
Biological Process: cell cycle; mitotic cell cycle; neural crest cell development; neural crest formation; nucleolus organization and biogenesis; regulation of translation; rRNA processing
Reference #:  Q14978 (UniProtKB)
Alt. Names/Synonyms: 140 kDa nucleolar phosphoprotein; HCV NS5A trans-regulated protein 13; HCV NS5A-transactivated protein 13; Hepatitis C virus NS5A-transactivated protein 13; KIAA0035; NOLC1; NOPP130; Nopp140; NS5ATP13; Nucleolar 130 kDa protein; Nucleolar and coiled-body phosphoprotein 1; nucleolar and coiled-body phosphprotein 1; Nucleolar phosphoprotein p130; nucleolar protein p130; P130
Gene Symbols: NOLC1
Molecular weight: 73,603 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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