a RAC1 guanine nucleotide exchange factor (GEF). Can induce membrane ruffling. Interacts with PAK kinases through its SH3 domain. Acts both as an activator and a downstream target for Cdc42. Its EGF-dependent phosphorylation activates its nucleotide exchange factor for Cdc42 and regulates its interaction with the E3 ligase Cbl, thus modulating Cbl-catalysed EGFR degradation. Its phosphorylation status is necessary to maintain the balance between normal signaling by EGFR and Src versus aberrant growth and transformation. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein kinase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: ephrin receptor signaling pathway; focal adhesion assembly; G-protein coupled receptor signaling pathway; Golgi organization and biogenesis; hemopoietic progenitor cell differentiation; lamellipodium assembly; negative regulation of epidermal growth factor receptor signaling pathway; nervous system development; positive regulation of apoptosis; positive regulation of growth hormone secretion; positive regulation of GTPase activity; positive regulation of protein binding; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; signal transduction