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Protein Page:

TPM1 a cytoskeletal protein that binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Defects in TPM3 are a cause of nemaline myopathy type 1 (NEM1). Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 9 C|9 36.27 cM
Cellular Component: cytoplasm; filamentous actin; muscle thin filament tropomyosin; myofibril; protein complex
Molecular Function: actin binding; actin filament binding; protein homodimerization activity; protein N-terminus binding; structural constituent of cytoskeleton; structural constituent of muscle
Biological Process: actin filament capping; actin filament organization; cardiac muscle contraction; embryonic development; in utero embryonic development; muscle filament sliding; negative regulation of cell migration; positive regulation of ATPase activity; positive regulation of cell adhesion; positive regulation of heart rate by epinephrine; positive regulation of stress fiber formation; regulation of ATPase activity; ruffle organization and biogenesis; ventricular cardiac muscle morphogenesis; wound healing
Reference #:  P58771 (UniProtKB)
Alt. Names/Synonyms: AA986836; AI854628; alpha tropomyosin; alpha-TM; Alpha-tropomyosin; OTTMUSP00000022205; TM2; Tm3; Tmpa; Tpm-1; Tpm1; Tpma; tropomyosin 1, alpha; Tropomyosin alpha-1 chain; Tropomyosin-1
Gene Symbols: Tpm1
Molecular weight: 32,681 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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