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PTPLA Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis. Belongs to the very long-chain fatty acids dehydratase HACD family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2|2 A1
Cellular Component: endoplasmic reticulum; integral to endoplasmic reticulum membrane
Molecular Function: 3-hydroxyacyl-CoA dehydratase activity; enzyme binding; hydroxyapatite binding
Biological Process: fatty acid elongation; myotube differentiation; regulation of G2/M transition of mitotic cell cycle; sphingolipid biosynthetic process; very-long-chain fatty acid biosynthetic process
Reference #:  Q9QY80 (UniProtKB)
Alt. Names/Synonyms: protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a; Protein-tyrosine phosphatase-like member A; Ptpla
Gene Symbols: Ptpla
Molecular weight: 32,327 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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