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Protein Page:

GHF-1 Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'- TAAAT-3'. Belongs to the POU transcription factor family. Class- 1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 3p11.2
Cellular Component: nucleus; transcription factor complex
Molecular Function: chromatin binding; DNA binding transcription factor activity; transcription corepressor activity
Biological Process: B cell differentiation; cell fate specification; determination of adult lifespan; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nuclear transport; positive regulation of cell proliferation; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of multicellular organism growth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of insulin-like growth factor receptor signaling pathway; regulation of transcription, DNA-templated; somatotropin secreting cell development; transcription from RNA polymerase II promoter
Disease: Pituitary Hormone Deficiency, Combined, 1
Reference #:  P28069 (UniProtKB)
Alt. Names/Synonyms: CPHD1; GHF-1; GHF1; Growth hormone factor 1; PIT-1; PIT1; Pituitary-specific positive transcription factor 1; pituitary-specific transcription factor 1; POU class 1 homeobox 1; POU domain, class 1, transcription factor 1; POU1F1
Gene Symbols: POU1F1
Molecular weight: 32,912 Da
Basal Isoelectric point: 8.36  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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