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ADCY6 a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Expressed in normal thyroid and brain tissues, as well as some tumors; its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component: guanylate cyclase complex, soluble; intrinsic to plasma membrane; membrane; plasma membrane
Molecular Function: adenylate cyclase activity; guanylate cyclase activity; protein binding; protein kinase binding
Biological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cGMP biosynthetic process; dopamine receptor signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; renal water homeostasis
Disease: Lethal Congenital Contracture Syndrome 8
Reference #:  O43306 (UniProtKB)
Alt. Names/Synonyms: AC6; ADCY6; adenylate cyclase 6; Adenylate cyclase type 6; Adenylate cyclase type VI; Adenylyl cyclase 6; ATP pyrophosphate-lyase 6; Ca(2+)-inhibitable adenylyl cyclase; DKFZp779F075; KIAA0422
Gene Symbols: ADCY6
Molecular weight: 130,615 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
Select Structure to View Below


Protein Structure Not Found.

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