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RARA is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARA is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Its phosphorylation is crucial for transcriptional activity. Aberrations involving RARA may be a cause of acute promyelocytic leukemia. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: actin cytoskeleton; cell soma; cell surface; cytoplasm; cytosol; dendrite; nuclear chromatin; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function: alpha-actinin binding; chromatin DNA binding; DNA binding transcription factor activity; drug binding; enzyme binding; histone deacetylase binding; mRNA 5'-UTR binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein kinase A binding; protein kinase B binding; receptor binding; retinoic acid binding; retinoic acid receptor activity; steroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; transcription factor binding; translation repressor activity, nucleic acid binding; zinc ion binding
Biological Process: apoptotic cell clearance; embryonic camera-type eye development; female pregnancy; germ cell development; glandular epithelial cell development; hippocampus development; limb development; liver development; multicellular organism growth; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of granulocyte differentiation; negative regulation of interferon-gamma production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of translational initiation; negative regulation of tumor necrosis factor production; neural tube closure; positive regulation of binding; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of neuron differentiation; positive regulation of T-helper 2 cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; prostate gland development; protein amino acid phosphorylation; regulation of myelination; regulation of synaptic plasticity; response to cytokine; response to estradiol; response to ethanol; response to retinoic acid; response to vitamin A; retinoic acid receptor signaling pathway; Sertoli cell fate commitment; signal transduction; spermatogenesis; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter; ureteric bud development; ventricular cardiac muscle cell differentiation
Disease: Acute Promyelocytic Leukemia
Reference #:  P10276 (UniProtKB)
Alt. Names/Synonyms: NR1B1; Nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR; RAR-alpha; RARA; Retinoic acid receptor alpha; retinoic acid receptor, alpha; Retinoic acid receptor, alpha polypeptide
Gene Symbols: RARA
Molecular weight: 50,771 Da
Basal Isoelectric point: 8.21  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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