Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

PRF1 Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Monomer, as sobluble protein. Homooligomer. Oligomerization is required for pore formation. Repressed by contact with target cells. Belongs to the complement C6/C7/C8/C9 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: cytosol; integral to membrane; membrane
Molecular Function: calcium ion binding; protein binding; wide pore channel activity
Biological Process: apoptosis; cellular defense response; cytolysis; defense response to tumor cell; defense response to virus; formation of immunological synapse; immune response to tumor cell; positive regulation of killing of cells of another organism; protein homooligomerization
Disease: Aplastic Anemia; Hemophagocytic Lymphohistiocytosis, Familial, 2; Lymphoma, Non-hodgkin, Familial
Reference #:  P14222 (UniProtKB)
Alt. Names/Synonyms: Cytolysin; FLH2; HPLH2; lymphocyte pore forming protein; Lymphocyte pore-forming protein; MGC65093; P1; PERF; perforin 1 (pore forming protein); Perforin-1; PFN1; PFP; PRF1
Gene Symbols: PRF1
Molecular weight: 61,377 Da
Basal Isoelectric point: 8.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene