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QPCT Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. Belongs to the glutaminyl-peptide cyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Secreted; Secreted, signal peptide; Transferase
Chromosomal Location of Human Ortholog: 17|17 E3
Molecular Function: glutaminyl-peptide cyclotransferase activity; zinc ion binding
Biological Process: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
Reference #:  Q9CYK2 (UniProtKB)
Alt. Names/Synonyms: 5730422A13Rik; Glutaminyl cyclase; Glutaminyl-peptide cyclotransferase; glutaminyl-peptide cyclotransferase (glutaminyl cyclase); Glutaminyl-tRNA cyclotransferase; QC; Qpct
Gene Symbols: Qpct
Molecular weight: 41,119 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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