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PIGK Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.-.-.-; Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 1p31.1
Cellular Component: endoplasmic reticulum membrane; GPI-anchor transamidase complex; membrane
Molecular Function: GPI-anchor transamidase activity; protein binding; protein disulfide isomerase activity
Biological Process: attachment of GPI anchor to protein
Reference #:  Q92643 (UniProtKB)
Alt. Names/Synonyms: GPI transamidase; GPI transamidase subunit; GPI-anchor transamidase; GPI8; GPI8 homolog; hGPI8; MGC22559; phosphatidylinositol glycan anchor biosynthesis, class K; phosphatidylinositol glycan, class K; Phosphatidylinositol-glycan biosynthesis class K protein; PIG-K; PIGK
Gene Symbols: PIGK
Molecular weight: 45,252 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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