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Protein Page:
DRD4

Overview
DRD4 Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: integral component of plasma membrane; membrane; plasma membrane
Molecular Function: dopamine binding; dopamine neurotransmitter receptor activity, coupled via Gi/Go; dopamine receptor activity; drug binding; identical protein binding; potassium channel regulator activity; protein binding; SH3 domain binding
Biological Process: activation of MAPK activity; adenylate cyclase-inhibiting dopamine receptor signaling pathway; adult locomotory behavior; arachidonic acid secretion; behavioral fear response; behavioral response to cocaine; behavioral response to ethanol; cellular calcium ion homeostasis; dopamine metabolic process; dopamine receptor signaling pathway; fear response; inhibitory postsynaptic potential; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of protein secretion; positive regulation of dopamine uptake involved in synaptic transmission; positive regulation of kinase activity; positive regulation of sodium:hydrogen antiporter activity; regulation of circadian rhythm; regulation of dopamine metabolic process; response to amphetamine; rhythmic process; social behavior
Disease: Attention Deficit-hyperactivity Disorder; Novelty Seeking Personality Trait
Reference #:  P21917 (UniProtKB)
Alt. Names/Synonyms: D(2C) dopamine receptor; D(4) dopamine receptor; D4DR; Dopamine D4 receptor; dopamine receptor D4; DRD4
Gene Symbols: DRD4
Molecular weight: 48,361 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Select Structure to View Below

DRD4

Protein Structure Not Found.
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