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DRD4 Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: integral component of plasma membrane; membrane; plasma membrane
Molecular Function: dopamine binding; dopamine neurotransmitter receptor activity, coupled via Gi/Go; dopamine receptor activity; drug binding; identical protein binding; potassium channel regulator activity; protein binding; SH3 domain binding
Biological Process: activation of MAPK activity; adenylate cyclase-inhibiting dopamine receptor signaling pathway; adult locomotory behavior; arachidonic acid secretion; behavioral fear response; behavioral response to cocaine; behavioral response to ethanol; cellular calcium ion homeostasis; dopamine metabolic process; dopamine receptor signaling pathway; fear response; inhibitory postsynaptic potential; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of protein secretion; positive regulation of dopamine uptake involved in synaptic transmission; positive regulation of kinase activity; positive regulation of sodium:hydrogen antiporter activity; regulation of circadian rhythm; regulation of dopamine metabolic process; response to amphetamine; rhythmic process; social behavior
Disease: Attention Deficit-hyperactivity Disorder; Novelty Seeking Personality Trait
Reference #:  P21917 (UniProtKB)
Alt. Names/Synonyms: D(2C) dopamine receptor; D(4) dopamine receptor; D4DR; Dopamine D4 receptor; dopamine receptor D4; DRD4
Gene Symbols: DRD4
Molecular weight: 48,361 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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