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HEYL Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Belongs to the HEY family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 1p34.2
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: AF-1 domain binding; protein binding; protein heterodimerization activity; transcription corepressor activity; transcription factor activity
Biological Process: mesenchymal cell development; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q9NQ87 (UniProtKB)
Alt. Names/Synonyms: BHLHB33; Class B basic helix-loop-helix protein 33; Hairy-related transcription factor 3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related with YRPW motif-like; Hairy/enhancer-of-split related with YRPW motif-like protein; HEY-like protein; HEY3; HEYL; hHeyL; hHRT3; HRT-3; HRT3; MGC12623
Gene Symbols: HEYL
Molecular weight: 35,087 Da
Basal Isoelectric point: 10.69  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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