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PIGO Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.-.-.-; Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: endoplasmic reticulum membrane; integral component of membrane; membrane
Molecular Function: mannose-ethanolamine phosphotransferase activity
Biological Process: GPI anchor biosynthetic process
Disease: Hyperphosphatasia With Mental Retardation Syndrome 2
Reference #:  Q8TEQ8 (UniProtKB)
Alt. Names/Synonyms: DKFZp434M222; FLJ00135; GPI ethanolamine phosphate transferase 3; MGC20536; MGC3079; phosphatidylinositol glycan anchor biosynthesis, class O; phosphatidylinositol glycan, class O; Phosphatidylinositol-glycan biosynthesis class O protein; PIG-O; PIGO; RP11-182N22.4
Gene Symbols: PIGO
Molecular weight: 118,699 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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