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Protein Page:

GLUT2 an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Present at high levels in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion, a glucose metabolism-dependent signaling mechanism. May mediate the bidirectional transfer of glucose across the plasma membrane of hepatocytes. May also participate with the Na( +2)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Required for glucose sensitivity in the hypothalamus and brain stem. Involved in the control of food intake and stimulation of glucose uptake by peripheral tissues. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component: apical plasma membrane; brush border; cytoplasm; integral component of plasma membrane; intercellular junction; membrane; plasma membrane
Molecular Function: D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; glucose transmembrane transporter activity; hexose transmembrane transporter activity
Biological Process: carbohydrate metabolic process; glucose transport; hexose transport; regulation of insulin secretion
Disease: Diabetes Mellitus, Noninsulin-dependent; Fanconi-bickel Syndrome
Reference #:  P11168 (UniProtKB)
Alt. Names/Synonyms: Glucose transporter type 2, liver; GLUT-2; GLUT2; GTR2; SLC2A2; solute carrier family 2 (facilitated glucose transporter), member 2; Solute carrier family 2, facilitated glucose transporter member 2
Gene Symbols: SLC2A2
Molecular weight: 57,490 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below


Protein Structure Not Found.

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