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XRCC1 Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 19q13.31
Cellular Component: nuclear chromatin; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus
Molecular Function: DNA ligase activity; enzyme binding; oxidized DNA binding; protein binding
Biological Process: base-excision repair; base-excision repair, DNA ligation; cerebellum morphogenesis; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; hippocampus development; nucleotide-excision repair, DNA gap filling; response to drug; response to hydroperoxide; response to hypoxia; response to organic substance; single strand break repair; transcription-coupled nucleotide-excision repair; voluntary musculoskeletal movement
Disease: Spinocerebellar Ataxia, Autosomal Recessive 26
Reference #:  P18887 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein XRCC1; RCC; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross complementing protein 1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster; XRCC1
Gene Symbols: XRCC1
Molecular weight: 69,477 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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