Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1. Note: This description may include information from UniProtKB.
Molecular Function: DNA ligase activity; enzyme binding; oxidized DNA binding; protein binding
Biological Process: base-excision repair; base-excision repair, DNA ligation; cerebellum morphogenesis; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; hippocampus development; nucleotide-excision repair, DNA gap filling; response to drug; response to hydroperoxide; response to hypoxia; response to organic substance; single strand break repair; transcription-coupled nucleotide-excision repair; voluntary musculoskeletal movement
Alt. Names/Synonyms: DNA repair protein XRCC1; RCC; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross complementing protein 1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster; XRCC1