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Protein Page:
G-alpha i2

G-alpha i2 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: centrosome; cytoplasm; cytosol; heterotrimeric G-protein complex; membrane; midbody; nucleoplasm; plasma membrane
Molecular Function: G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; GTP binding; GTPase activity; protein binding; signal transducer activity
Biological Process: adenosine receptor signaling pathway; cell division; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; gamma-aminobutyric acid signaling pathway; negative regulation of adenylate cyclase activity; protein folding; response to nutrient; signal transduction
Disease: Ventricular Tachycardia, Familial
Reference #:  P04899 (UniProtKB)
Alt. Names/Synonyms: Adenylate cyclase-inhibiting G alpha protein; GIP; GNAI2; GNAI2B; GTP-binding regulatory protein Gi alpha-2 chain; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-2 subunit; H_LUCA15.1; H_LUCA16.1
Gene Symbols: GNAI2
Molecular weight: 40,451 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Hedgehog Signaling  |  Microtubule Dynamics  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling
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G-alpha i2

Protein Structure Not Found.

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