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ID2 ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component: cytoplasm; cytosol; nucleus; protein complex
Molecular Function: protein binding; protein dimerization activity
Biological Process: circadian regulation of gene expression; embryonic digestive tract morphogenesis; entrainment of circadian clock by photoperiod; locomotor rhythm; mammary gland epithelial cell proliferation; multicellular organism development; negative regulation of neuron differentiation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; neuron fate commitment; positive regulation of blood pressure; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-templated; regulation of circadian rhythm; regulation of lipid metabolic process; transcription, DNA-dependent
Reference #:  Q02363 (UniProtKB)
Alt. Names/Synonyms: BHLHB26; cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; GIG8; helix-loop-helix protein ID2; ID2; ID2A; ID2H; inhibitor of differentiation 2; Inhibitor of DNA binding 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; MGC26389
Gene Symbols: ID2
Molecular weight: 14,917 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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