Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

Vinculin Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Exhibits self-association properties. Interacts with NRAP and SORBS1. Interacts with TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin. Metavinculin is muscle-specific. Belongs to the vinculin/alpha-catenin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q22.2
Cellular Component: adherens junction; cell-cell adherens junction; cell-matrix junction; costamere; cytoskeleton; cytosol; extracellular region; fascia adherens; focal adhesion; intercellular junction; podosome; protein complex; sarcolemma
Molecular Function: actin binding; alpha-catenin binding; beta-catenin binding; cadherin binding; protein binding; structural molecule activity; ubiquitin protein ligase binding
Biological Process: apical junction assembly; axon extension; cell adhesion; cell motility; cell-matrix adhesion; lamellipodium assembly; morphogenesis of an epithelium; muscle contraction; negative regulation of cell migration; neutrophil degranulation; platelet degranulation
Disease: Cardiomyopathy, Dilated, 1w
Reference #:  P18206 (UniProtKB)
Alt. Names/Synonyms: CMD1W; CMH15; Metavinculin; MVCL; VCL; VINC; Vinculin
Gene Symbols: VCL
Molecular weight: 123,799 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein